AIM: To evaluate the prognostic significance of initial central nervous system (CNS) involvement of children with acute lymphoblastic leukemia (ALL) enrolled in the EORTC 58951 trial. PATIENTS AND METHODS: From 1998 to 2008, 1930 ALL patients were included in the randomized EORTC 58951 trial. Overall treatment intensity was adjusted according to known prognostic factors including the level of minimal residual disease after induction treatment. CNS-directed therapy comprised four to 11 courses of i.v. methotrexate (5g/m2), and 10 to 19 intrathecal chemotherapy injections, depending on risk group and CNS status. Cranial irradiation was omitted for all patients. RESULTS: The overall 8-year event-free survival (EFS) and overall survival (OS) rates were 81.3% and 88.1%, respectively. In the CNS-1, TPL+, CNS-2, and CNS-3 groups, the 8-year EFS rates were 82.1%, 77.1%, 78.3%, and 57.4%, respectively. Multivariable analysis indicated that initial CNS-3 status, but not CNS-2 or TLP+, was an independent adverse predictor of outcome. The 8-year incidence of isolated CNS relapse was 1.7% and of isolated or combined CNS relapse it was 3.7%. NCI high-risk group, male sex, CNS-2 and CNS-3 status were independent predictors for a higher incidence of any CNS relapse. CONCLUSIONS: CNS-3 status remains associated with poor prognosis and requires intensification of both systemic and CNS-directed therapy. This trial was registered at https://clinicaltrials.gov/under/NCT00003728.
Central Nervous System/abnormalities , Precursor Cell Lymphoblastic Leukemia-Lymphoma/diagnosis , Predictive Value of Tests , Adolescent , Biomarkers, Tumor/analysis , Central Nervous System/physiopathology , Child , Child, Preschool , Cranial Irradiation/trends , Female , Humans , Infant , Male , Pediatrics/methods , Precursor Cell Lymphoblastic Leukemia-Lymphoma/complications , Prognosis , Treatment Outcome
A vascular mass localized in the face and the neck was displayed by ultrasonography in a 38-week-old male fetus. At birth, the mass was bulky and purplish. The newborn breathed spontaneously but with severe desaturation. During laryngoscopy, we observed an obstruction of the larynx with a left-shift caused by the hemorrhagic mass. Blood analysis revealed anemia, severe thrombocytopenia, and coagulation disorders. The diagnosis of kaposiform hemangioendothelioma (KHE) complicated by a Kasabach-Merritt phenomenon (KMP) was put forward and treatment with propranolol, corticoids, and vincristine was initiated. Platelets were transfused daily for 8 days but did not resolve the thrombocytopenia. At day 8, we added sirolimus to the treatment and noted a rapid response with the normalization of the platelet count within 1 week and a significant regression of the mass. In this paper, we review the clinical and biological features of hemangioendothelioma associated with KMP and discuss its current and future treatment. Sirolimus seems to be very promising.
Hemangioendothelioma/diagnosis , Kasabach-Merritt Syndrome/diagnosis , Sarcoma, Kaposi/diagnosis , Combined Modality Therapy , Hemangioendothelioma/therapy , Humans , Infant, Newborn , Kasabach-Merritt Syndrome/therapy , Male , Sarcoma, Kaposi/therapy
Cancer is the second leading cause of death among children aged 5 to 14, after accidents. We conducted a study on the epidemiology of childhood cancer in the university pediatric oncology department of the CHU-CHR in Liège, Belgium. We studied a cohort of 662 patients between the ages of 0 and 17 whose malignancy diagnosis was made between 1985 and 2016. The analyzes were performed retrospectively using medical files. The number of new cases, the proportion of different cancers, sex ratio, age at diagnosis and survival at 5 and 10 years were the epidemiological factors studied.We have been able to show an increase in the number of new diagnoses per year. More than 40 % of childhood cancers occur before the age of five. The most common neoplasias are leukemias, tumors of the central nervous system and lymphomas. This distribution is influenced by age. All malignant tumours combined, we observed a slightly larger proportion of affected boys than girls. Overall survival at 5 years reaches 80.2 %. However, it varies according to the type of tumour from 59.3 % for malignant soft tissue tumors up to 100 % for hepatoblastomas.
Le cancer est la deuxième cause de décès chez les enfants de 5 à 14 ans, après les accidents. Nous avons réalisé une étude sur l'épidémiologie des cancers de l'enfant au sein du service universitaire d'oncologie pédiatrique du CHU-CHR de Liège. Nous avons étudié une cohorte de 662 patients, âgés de 0 à 17 ans, dont le diagnostic de tumeur maligne a été posé entre 1985 et 2016. Le nombre de nouveaux cas, la proportion des différents cancers, le sex ratio, l'âge au diagnostic et la survie à 5 et 10 ans ont été les facteurs épidémiologiques étudiés. Nous avons pu démontrer une augmentation du nombre de nouveaux diagnostics par an. Plus de 40 % des cancers de l'enfant surviennent avant l'âge de 5 ans. Les néoplasies les plus fréquentes sont les leucémies, les tumeurs du système nerveux central et les lymphomes. Cette répartition est néanmoins influencée par l'âge. Toutes tumeurs malignes confondues, nous avons observé une proportion légèrement plus grande de garçons atteints que de filles. La survie globale à 5 ans s'élève à 80,2 %. Elle varie cependant selon le type de tumeur de 59,3 % pour les tumeurs malignes des tissus mous jusqu'à 100 % pour les hépatoblastomes.
Neoplasms , Adolescent , Belgium/epidemiology , Child , Child, Preschool , Female , Humans , Incidence , Infant , Infant, Newborn , Male , Neoplasms/epidemiology , Retrospective Studies
Bone pain associated with bone marrow infiltration is often present at diagnosis of pediatric acute lymphoblastic leukemia (ALL). It sometimes signs the presence of pathological fracture, lytic lesions, arthritis, or osteitis associated to ALL that can delay the diagnosis. During treatment, bone complications (pain, osteopenia, fracture, avascular necrosis, ...) are also reported. In order to describe bone involvement (BI) of pediatric LLA, we reviewed the records of 104 patients followed in our unit. The overall incidence of BI was 67 %. At diagnosis, 50 % of patients had BI and in 19 %, the diagnosis of ALL was delayed. During and after treatment, respectively 28 % and 37 % of patients presented bone complications (pain, fractures, avascular necrosis, osteopenia). Patients with BI had a lower leukocytosis inferior to 10x109/l (p = 0.005) and an ALL of average risk (p = 0.019). 38 % of patients with BI during treatment were over 10 years old and 55 % were girls (vs. 21 % and 38 % in the entire cohort, respectively). Osteoporosis was more severe at diagnosis than during treatment, suggesting the presence of constitutional promoting factors. In our cohort, the majority of BI was resolved at the end of treatment with no long-term sequelae.
Des douleurs osseuses sont souvent présentes au diagnostic des leucémies lymphoblastiques aiguës (LLA) pédiatriques. Elles signent aussi parfois la présence de fracture pathologique, de lésions lytiques, d'arthrite, ou d'ostéite associées qui peuvent retarder le diagnostic. Lors des traitements, des complications osseuses (douleurs, ostéopénie, fracture, nécrose avasculaire, ) sont également rapportées. Afin de décrire les atteintes osseuses (AO) des LLA pédiatriques, nous avons revu les dossiers de 104 patients suivis dans notre unité. L'incidence globale des AO était de 67 %. Au diagnostic, 50 % des patients avaient une AO et, chez 19 % d'entre eux, le diagnostic de LLA a été retardé. Pendant et après les traitements, respectivement 28 et 37 % des patients ont présenté des complications osseuses (douleurs, fractures, nécrose avasculaire, ostéopénie). Les patients avec AO avaient une leucocytose plus basse inf�rieur a 10x109/l (p = 0,005) et une LLA de risque moyen (p = 0,019). Chez les patients avec AO pendant les traitements, 38 % avaient plus de 10 ans et 55 % étaient des filles (vs 21 % et 38 % dans la cohorte entière). L'ostéoporose était plus sévère au diagnostic que pendant les traitements, suggérant la présence de facteurs favorisants constitutionnels. Dans notre cohorte, la majorité des AO étaient résolues après les traitements de LLA sans séquelles à long terme.
Bone Diseases, Metabolic/etiology , Fractures, Spontaneous/etiology , Osteonecrosis/etiology , Pain/etiology , Precursor Cell Lymphoblastic Leukemia-Lymphoma/complications , Child , Female , Humans , Male , Retrospective Studies
Vascular anomalies (VAs) result from the defective development of the embryonic vascular system and feature dysplastic malformed vessels, which are not always apparent at birth. They do not regress over the patient's lifetime; they usually have commensurate growth during childhood and may worsen over time if not treated. VAs may cause chronic painful swelling, bleeding, functional deficits or vital structure obstruction. These patients' quality of life is usually impaired because of the chronicity and recurrence of the disease. We report on six cases of complicated VAs, refractory to current treatments, treated with rapamycin, an mTor inhibitor recently used in VAs.
Angiogenesis Inhibitors/therapeutic use , Sirolimus/therapeutic use , Vascular Malformations/drug therapy , Adolescent , Child, Preschool , Female , Humans , Infant , Male , TOR Serine-Threonine Kinases/antagonists & inhibitors , Young Adult
Rectal prolapse is rare in children and usually benign. However, there are various diseases that can be associated with it, such as cystic fibrosis or other causes of increased abdominal pressure. Here, we review the various underlying conditions that pediatricians or pediatric gastroenterologists should consider in the case of rectal prolapse. We report on three cases of children with a rectal prolapse and intra-abdominal tumors. Current recommendations and practice do not include a systematic check via abdominal imaging in cases of rectal prolapse. However, in some situations, imaging is indicated to detect a possible expansive process. Thus, in the presence of recurrent prolapse or of associated urinary or neurological signs, imaging is justified so as to allow for an early diagnosis and treatment of these neoplasms. Given its lack of radiation exposure and good sensitivity in children, ultrasound imaging is the first choice.
Abdominal Neoplasms/complications , Rectal Prolapse/etiology , Urinary Bladder Neoplasms/complications , Abdominal Neoplasms/diagnostic imaging , Abdominal Neoplasms/pathology , Child, Preschool , Female , Humans , Infant , Male , Neuroblastoma/complications , Neuroblastoma/diagnostic imaging , Neuroblastoma/pathology , Rhabdomyosarcoma/diagnostic imaging , Rhabdomyosarcoma/pathology , Rhabdomyosarcoma, Embryonal/complications , Rhabdomyosarcoma, Embryonal/diagnostic imaging , Rhabdomyosarcoma, Embryonal/pathology , Ultrasonography , Urinary Bladder Neoplasms/diagnostic imaging , Urinary Bladder Neoplasms/pathology
Failure of the anterior neuropore can lead to three main types of anomalies: nasal dermal sinus, encephalocele and nasal glioma or heterotopia. In this report, we describe a case of intracranial and extracranial glial heterotopia that probably resulted from a common failure of anterior neuropore development. We describe the prenatal radiological assessment based on ultrasound and MRI results, and consider their limitation for early fetal diagnosis. We also discuss the embryogenesis and the possible pathogenic mechanisms involved.
Astrocytoma/surgery , Glioma/surgery , Nose Neoplasms/surgery , Astrocytoma/diagnosis , Diagnosis, Differential , Encephalocele/diagnosis , Encephalocele/surgery , Glioma/diagnosis , Humans , Infant , Magnetic Resonance Imaging/methods , Male , Nose Neoplasms/diagnosis
Paravertebral malignant tumors constitute 4.8% of cancer cases in pediatric oncology and are mostly composed of neuroblastoma (46.4%) and soft tissue sarcomas (35.7%). We describe the case of a Caucasian 6-year-old boy who was admitted for middle back pain radiated to limbs and progressively increasing weakness of the legs, suggesting a spinal cord disease. The exploration revealed two paravertebral masses extending through the neural foraminae into the epidural space. The association with elevated serum neuron specific enolase suggested at first the diagnosis of neuroblastoma, but the pathological examination revealed a Burkitt's lymphoma. This is a rare location of sporadic Burkitt's lymphoma with neurologic syndrome as first symptoms.
Germ cell tumours represent about 3 to 8% of pediatric brain tumours. Occurrence of diabetes insipidus is common in the case of suprasellar germ cell tumors. The diagnosis may be advanced by MRI owing to the location and relatively univocal characteristics of the lesion signal. The existence of a bifocal mass developed in both suprasellar region and pineal zone is highly suggestive of a germinoma. The most important notion is to recognize that at the time of diabetes insipidus diagnosis in a child, the cerebral mass might be too small to be identified by MRI. In such patients, repeating imaging study should be obtained.
Germinoma/diagnosis , Magnetic Resonance Imaging/methods , Pituitary Neoplasms/diagnosis , Biopsy , Child , Contrast Media , Diabetes Insipidus/etiology , Diagnosis, Differential , Female , Germinoma/pathology , Humans
We describe a 6-year-old boy who developed Borrelia burgdorferi-associated lymphocytoma cutis on the ear. Lymphocytoma is a benign polyclonal B-cell lymphoproliferative process; it is defined as a subacute manifestation of early disseminated borrelial infection. Clinical history, physical examination, and serodiagnosis tests are often sufficient to establish diagnosis, but sometimes, histopathologic analysis is needed to exclude malignant cutaneous lymphomas. The outcome is always favorable but after antibiotic therapy, the lesion disappears promptly.
Anti-Bacterial Agents/therapeutic use , Lyme Disease/complications , Pseudolymphoma/etiology , Skin Diseases/etiology , Administration, Oral , Anti-Bacterial Agents/administration & dosage , Biopsy , Borrelia burgdorferi , Child , Ear/pathology , Humans , Lyme Disease/drug therapy , Male , Pseudolymphoma/drug therapy , Pseudolymphoma/microbiology , Pseudolymphoma/pathology , Skin Diseases/drug therapy , Skin Diseases/microbiology , Skin Diseases/pathology , Treatment Outcome
UNLABELLED: Infantile pyknocytosis (IP) is a rare hematological entity of newborns. It is a form of hemolytic anemia with unusual red cell morphology: the red blood cells are distorted, irregular, and small with many projections. Spontaneous resolution usually occurs by 4-6months of age. OBSERVATION: We describe the clinical features and biological parameters of 5 cases of IP. The first symptoms were always early jaundice, which required phototherapy. Anemia was severe in all babies and red blood cell transfusion was needed. CONCLUSION: IP is a rare cause of neonatal anemia whose diagnosis is based on a careful peripheral blood smear examination. In our study, anemia was severe and required red blood cell transfusion. Ethnic specificity and familial occurrence are reported in our experience.
Anemia, Hemolytic , Anemia, Neonatal , Erythrocytes, Abnormal , Age Factors , Anemia, Hemolytic/blood , Anemia, Hemolytic/diagnosis , Anemia, Hemolytic/therapy , Anemia, Neonatal/blood , Anemia, Neonatal/diagnosis , Anemia, Neonatal/therapy , Apgar Score , Erythrocyte Transfusion , Female , Follow-Up Studies , Gestational Age , Humans , Infant , Infant, Newborn , Jaundice, Neonatal/diagnosis , Jaundice, Neonatal/therapy , Male , Phototherapy , Remission, Spontaneous , Retrospective Studies , Time Factors
Hemangioma is the most benign vascular tumor encountered in infancy; its incidence is 10-12% at 1 year of age. It usually appears a few weeks after birth, and rather rapidly grows until the age of 10-12 months; it then stabilizes and spontaneously regresses towards a complete disappearance over 5 - 10 years. Therefore, most hemangiomas need no treatment, but just a close clinical follow up. However, some hemangiomas (10-20% of cases), because of their location and/or complications, can have very serious aesthetic, functional, or even vital consequences: these require a more aggressive approach. A pharmacologic initial therapy based on high doses of corticosteroids or interferon alpha 2a or 2b has gained wide acceptance, but can entail serious side-effects. Vincristine represents a safe and effective treatment option for the management of those alarming hemangiomas.
Antineoplastic Agents, Phytogenic/therapeutic use , Hemangioma/drug therapy , Vincristine/therapeutic use , Head and Neck Neoplasms/drug therapy , Humans , Infant , Skin Neoplasms/drug therapy
We present the experience of the Citadelle Hospital (Liege, B) in the diagnosis, treatment and follow-up of medulloblastoma in children. A retrospective study of 10 cases of medulloblastoma was performed. Five years after diagnosis, the event-free survival was 77%.
Brain Neoplasms/surgery , Medulloblastoma/surgery , Adolescent , Belgium , Brain Neoplasms/diagnosis , Brain Neoplasms/genetics , Chemotherapy, Adjuvant , Child , Child Development , Child, Preschool , Diagnosis, Differential , Disease-Free Survival , Female , Follow-Up Studies , Humans , Infant , Intracranial Hypertension/surgery , Male , Medulloblastoma/diagnosis , Medulloblastoma/genetics , Neoplasm Recurrence, Local/pathology , Radiotherapy, Adjuvant , Remission Induction , Retrospective Studies , Treatment Outcome
Screening for childhood primary malignancy is not a routine practicable issue, due to the rarity of the disease, the absence of specific indicators and the largely unknown causes of childhood cancer. Genetic predisposition may account for as much as 4% of childhood cancer; environmental factors are though to play a smaller role than in the aetiology of adult malignancy: gene-environment interactions could well be important in the induction of malignant disease. Although knowledge about childhood cancer continues to increase, there is much work to be accomplished before reliable preventative measures and screening programme can be recommended. Epidemiologic studies have provided important clues to the etiology of childhood cancer; further insights may be possible by incorporating genomic technology into epidemiologic studies to evaluate cancer susceptibility and to identify high risk children population for cancer. Since second malignancies remain a significant threat to the health of survivors treated for cancer during childhood, vigilant screening is important for those at risk.
Mass Screening , Neoplasms/prevention & control , Adolescent , Child , Child, Preschool , Environment , Genetic Predisposition to Disease , Genetic Techniques , Humans , Infant , Neoplasms/genetics , Neoplasms, Second Primary/etiology , Risk Factors
The first EORTC (European Organization of Research and Treatment of Cancer) acute myeloblastic leukemia (AML) pilot study (58872) was conducted between January 1988 and December 1991. Out of 108 patients, 78% achieved complete remission (CR), and event-free survival (EFS) and survival rates (s.e., %) at 7 years were 40 (5) and 51% (6%), respectively. It indicated that mitoxantrone could be substituted for conventional anthracyclines in the treatment of childhood AML without inducing cardiotoxicity. The aim of the next EORTC 58921 trial was to compare the efficacy and toxicity of idarubicin vs mitoxantrone in initial chemotherapy courses, further therapy consisting of allogeneic bone marrow transplantation (alloBMT) in patients with an HLA-compatible sibling donor or chemotherapy in patients without a donor. Out of 177 patients, recruited between October 1992 and December 2002, 81% reached CR. Overall 7-year EFS and survival rates were 49 (4) and 62% (4%), respectively. Out of 145 patients who received the first intensification, 39 had a sibling donor. In patients with or without a donor, the 7-year disease-free survival (DFS) rate was 63 (8) and 57% (5%) and the 7-year survival rate was 78 (7) and 65% (5%), respectively. Patients with favorable, intermediate and unfavorable cytogenetic features had a 5-year EFS rate of 57, 45 and 45% and a 5-year survival rate of 89, 67 and 53%, respectively.
Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Antineoplastic Protocols/standards , Bone Marrow Transplantation , Leukemia, Myeloid, Acute/therapy , Adolescent , Child , Child, Preschool , Female , Follow-Up Studies , Humans , Idarubicin/therapeutic use , Infant , Infant, Newborn , Leukemia, Myeloid, Acute/mortality , Male , Mitoxantrone/therapeutic use , Remission Induction , Survival Rate , Transplantation, Homologous
Childhood lymphomas represent a heterogeneous group of disorders that are quite different from adult lymphomas. Over the past three decades, empirical chemotherapeutic management has transformed survival figures, and more recently greater understanding of the biology is offering hope for improved management of resistant disease. We present here the experience of a single institution in the management of 27 childhood lymphomas; epidemiological and clinical characteristics are described as well as survival rates. The median follow up of the patients is 4 years 7 months. The five-year overall survival for the entire group is more than 95 %; the 5-year disease free survival is 91,6 % for Hodgkin's lymphomas, 92,8% for non Hodgkin's lymphomas and 100% for Burkitt diseases. Two relapses have occurred and all of them appeared within the 18 months of the diagnosis. No toxic death has been reported.
Lymphoma/therapy , Adolescent , Child , Child, Preschool , Disease-Free Survival , Female , France , Humans , Incidence , Infant , Infant, Newborn , Lymphoma/epidemiology , Lymphoma/pathology , Male , Retrospective Studies , Treatment Outcome
Bacterial infections remain a major cause of morbidity and mortality among young children with sickle cell disease. Susceptibility to infections is mainly observed in homozygous sickle cell disease. The incidence of bacteremias in children under 3 years of age is approximately 8 events/100 patient-years among homozygous subjects and approximately S events/100 patient-years among those with SC hemoglobinopathy. Pneumococci and Salmonellae are the most frequently isolated bacteria. Severe clinical manifestations include septicemia, meningitis, osteomyelitis and pneumonia. M. Pneumoniae and C. Pneumoniae infections may be severe and may induce acute chest syndrome. The high incidence and severity of bacterial infections in these children justify prevention efforts by antibiotic prophylaxis and vaccination. The efficacy of oral penicillin prophylaxis against pneumococcal infections has been well demonstrated and is now recommended from 3 months of age. The antipneumococcal conjugate vaccine has been shown to be safe and immunogenic in young infants.
Anemia, Sickle Cell/complications , Bacterial Infections/complications , Bacterial Infections/prevention & control , Anemia, Sickle Cell/physiopathology , Antibiotic Prophylaxis , Humans , Influenza Vaccines/administration & dosage , Pneumococcal Vaccines/administration & dosage
Sharp's syndrome, or mixed connective tissue disease, is an autoimmune chronic disease characterized by a tissue collagen abnormality. It is more common among young women, but is also described in children. The symptomatology may be different from one case to another as shown in the two presented cases. Signs and symptoms of other rheumatic diseases are commonly observed. The presence of anti-RNP antibody is requested to confirm the diagnosis. The treatment is adapted to each individual. Non-steroidal anti-inflammatory drugs, corticosteroids, and immunosuppressive drugs are the basis of treatment.
Mixed Connective Tissue Disease , Adolescent , Child , Female , Humans , Mixed Connective Tissue Disease/diagnosis , Mixed Connective Tissue Disease/drug therapy
This is the medical history of a 6 month old baby who suffers from retarded weight gain. The difficulties encountered in establishing the diagnosis are outlined.
Brain Neoplasms/diagnosis , Cachexia/etiology , Glioma/diagnosis , Brain Neoplasms/complications , Child Development , Diagnosis, Differential , Glioma/complications , Humans , Hypothalamic Diseases/complications , Hypothalamic Diseases/diagnosis , Hypothalamus/pathology , Infant , Magnetic Resonance Imaging , Male , Weight Loss
